Related Experiment Video
Updated: Jul 3, 2026
08:35
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
20.7K
A novel engineered skin closes full thickness burn wounds: A case report
Shiva Akbarzadeh1,2, Elad Zvi3, Carlos L Arellano1,2
1Skin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, Melbourne, Victoria, Australia.
JPRAS Open
|April 20, 2026
Summary
A novel bioengineered skin substitute, Platelet-Rich Plasma Human Skin Equivalent (PG-HSE), successfully healed severe burns in a child. This innovative graft achieved a 95% take rate, demonstrating its potential for treating extensive full-thickness injuries.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Wound Healing Research
Background:
- Severe burns necessitate advanced wound closure techniques.
- Current skin substitutes have limitations in efficacy and application.
- Bioengineered skin offers a promising alternative for extensive burn treatment.
Purpose of the Study:
- To evaluate the initial clinical use of a novel bioengineered bilaminar skin substitute.
- To assess the efficacy of a Platelet-Rich Plasma Human Skin Equivalent (PG-HSE) in treating a pediatric patient with extensive full-thickness burns.
- To determine the graft take rate and long-term outcomes of PG-HSE.
Main Methods:
- A novel bioengineered bilaminar skin substitute (PG-HSE) was manufactured from a small skin biopsy.
- PG-HSE was applied to an excised wound bed previously treated with NovoSorb® Biodegradable Temporizing Matrix (BTM).
- Graft take rate and wound healing were monitored over 15 months post-application.
Main Results:
- The PG-HSE achieved a 95% take rate at 2 weeks post-grafting.
- No wound breakdown or need for further surgery was observed at the graft sites after 15 months.
- The bioengineered skin autograft effectively closed the temporized full-thickness burns.
Conclusions:
- The novel PG-HSE demonstrates significant efficacy in achieving durable healing of severe, full-thickness burns.
- This bioengineered skin substitute represents a viable option for managing extensive burn wounds.
- The use of PG-HSE in conjunction with biodegradable temporizing matrices shows promising clinical outcomes.
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