Functionalized boron nitride nanomaterials: Exploring antioxidant and antitumor activities for advanced therapeutic
Jialin Zang1,2, Zhen Lv1,3, Chunpeng Yang1,2
1Qiqihar Medical University, Qiqihar, Heilongjiang Province 161006, P.R. China.
Abstract:
Fluorinated boron nitride rods (F-BNs) are functional nanomaterials with tunable surface chemistry and emerging bioapplications. Here, F-BN samples with increasing fluorination levels (F-BN-1 to F-BN-3) were synthesized, and their antioxidant activity and cellular responses were systematically evaluated. Enhanced fluorination led to progressively stronger radical scavenging, with F-BN-3 showing IC50 values of 31.13 ± 0.31 μM (DPPH) and 26.67 ± 0.09 μM (ABTS). Cellular assays revealed moderate growth inhibition by F-BN-3 in tumor cells, with IC50 values of 48.89 ± 0.49 μM (HeLa), 27.5 ± 2.7 μM (A549), and 32.9 ± 2.2 μM (HepG2), while a higher IC50 (86.6 ± 5.4 μM) in normal L02 cells indicated better tolerance. These findings demonstrate that fluorination effectively modulates BN biointeractions, enabling tunable antioxidant behavior and differential cellular responses. The low intrinsic cytotoxicity and high stability observed in vitro suggest promising preliminary biocompatibility and potential for biomedical applications, pending in vivo validation.
