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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
Published on: August 4, 2023
Enduring coagulopathy and endothelial dysfunction in postacute COVID-19 syndrome.
Yucan Li1, Tichao Shan2, Zhengqi Jiang1
1Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
Long COVID, or Postacute COVID-19 Syndrome (PACS), involves persistent coagulation abnormalities. Many patients show elevated D-dimer and incomplete recovery of clotting factors, suggesting a chronic thromboinflammatory condition requiring ongoing monitoring.
Area of Science:
- Medical Research
- Hematology
- Infectious Diseases
Background:
- Postacute coronavirus disease 2019 (COVID-19) syndrome (PACS), or long COVID, is characterized by persistent symptoms after acute infection.
- While acute COVID-19 involves coagulation disturbances, long-term changes and their link to PACS are not well understood.
Purpose of the Study:
- To investigate long-term coagulation and inflammatory marker changes in PACS patients.
- To elucidate pathological mechanisms and inform patient management strategies for long COVID.
Main Methods:
- Retrospective cohort study of 3783 inpatients (363 with PACS).
- Analysis of coagulation and inflammatory markers at baseline and 1-year follow-up.
- Generalized estimating equations used to analyze changes over time.
Main Results:
- Most inflammatory markers and some coagulation parameters (e.g., fibrinogen) recovered.
- D-dimer and erythrocyte sedimentation rate remained significantly elevated at 7-12 months post-infection.
- Prothrombin time and platelet counts showed incomplete normalization in some patients.
Conclusions:
- PACS may be a chronic thromboinflammatory syndrome with sustained coagulation abnormalities.
- Prolonged D-dimer elevation and incomplete coagulation recovery necessitate long-term monitoring for thrombotic risk in COVID-19 survivors.
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