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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Apr 21, 2026

Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection
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Does grapiprant reduce osteoarthritic pain in dogs?

Grace Olding1, Merran Govendir1

  • 1The University of Sydney Australia.

Veterinary Evidence
|April 20, 2026
PubMed
Summary

Grapiprant may improve owner- and veterinarian-assessed outcomes for dogs with osteoarthritis, but evidence is inconsistent regarding its effect on lameness in acute, severe cases. Further research is needed to confirm its efficacy in managing canine osteoarthritic pain.

Keywords:
CANINEDOGEP-4 ANTAGONISTGRAPIPRANTOSTEOARTHRITIS

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Area of Science:

  • Veterinary Medicine
  • Pharmacology
  • Canine Health

Background:

  • Osteoarthritis is a common degenerative joint disease in dogs.
  • Managing osteoarthritic pain is crucial for maintaining a dog's quality of life.
  • Grapiprant is a non-steroidal anti-inflammatory drug (NSAID) used in veterinary medicine.

Purpose of the Study:

  • To evaluate the efficacy of grapiprant in reducing osteoarthritic pain in dogs.
  • To compare the effects of grapiprant versus placebo in canine osteoarthritis management.

Main Methods:

  • A systematic review of two randomized controlled trials was conducted.
  • Studies assessed owner-reported outcomes (pain interference, severity) and veterinarian-assessed outcomes (lameness, orthopaedic scores).

Main Results:

  • One study showed significant improvements in owner-assessed outcomes and veterinarian-assessed orthopaedic scores in dogs treated with grapiprant compared to placebo.
  • The second study found no significant difference in lameness scores or vertical force ratios between grapiprant and control groups in dogs with acute induced arthritis.

Conclusions:

  • Grapiprant may alleviate the impact of osteoarthritis on daily activities and orthopaedic status in dogs.
  • Evidence is limited and inconsistent regarding grapiprant's effectiveness, particularly for acute, severe pain and lameness.
  • Further high-quality studies are required to establish the definitive efficacy of grapiprant for canine osteoarthritis.