Related Experiment Video
Updated: Apr 26, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
A comprehensive review on structural, chemical, and functional perspectives of dietary polysaccharide-driven gut
Athira Jayasree Subhash1, Mohamed Abdin1,2, Gafar Babatunde Bamigbade1
1Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates.
Abstract:
Polysaccharides in the diet have been increasingly recognized as major modulators of gut microbiota and multifunctional ingredients in food systems. Despite extensive research on various polysaccharides regarding their prebiotic activities, a comprehensive approach towards an integration of structural characteristics, chemical modifications, mechanistic degradation pathways, and food processing effects is still limited. This review aims to compile existing knowledge regarding the molecular characteristics of polysaccharides, including their monosaccharide composition, glycosidic linkages, branching, and molecular weight, in relation to their utilization by gut microbiota, production of short-chain fatty acids, and associated metabolic effects in the human body. Furthermore, this review will focus on carbohydrate-active enzymes and cross-feeding effects that play a major role in determining the biological activities of polysaccharides. The effects of food processing and food systems on polysaccharide functionality and utilization will also be considered. Despite promising therapeutic and nutritional potential, existing inconsistencies in research methods and a lack of standardized approaches in studying mechanistic effects are major hurdles in developing novel food systems that are targeted towards modulating gut microbiota.
More Related Videos
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
13:35Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Related Concept Videos
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Probiotics
Introduction to the Human Microbiota
Microbiota of the Large Intestine
Functions of the Gut Microbiota
Gut-Brain Axis