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Advancements in targeted therapy for gastric cancer

Yihua Wang1, Jie Li1, Guanmo Liu1

  • 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Therapeutic Advances in Gastroenterology
|April 20, 2026
PubMed

Insights

Targeted therapies offer new hope for advanced gastric cancer (GC) by exploiting specific molecular pathways. These novel treatments improve survival rates for patients with this prevalent gastrointestinal malignancy.

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Biology

Background:

  • Gastric cancer (GC) is a leading gastrointestinal malignancy with poor prognoses for advanced stages post-surgery.
  • Current treatments like chemotherapy and immunotherapy have limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review recent advancements in targeted therapies for advanced gastric cancer.
  • To highlight the potential of targeted agents in precision oncology and guide future drug discovery.

Main Methods:

  • Literature review of recent studies on targeted therapies for gastric cancer.
  • Analysis of molecular targets and their therapeutic implications.

Main Results:

  • Targeted therapies exploit specific molecular vulnerabilities including HER2, Claudin 18.2, VEGF/VEGFR, FGFR2, and N6-methyladenosine pathways.
  • These agents demonstrate significant potential in suppressing tumor proliferation and extending overall survival.

Conclusions:

  • Targeted therapeutics represent a promising strategy for improving clinical outcomes in advanced gastric cancer.
  • Further research and drug discovery in this area are crucial for advancing precision oncology paradigms.
Keywords:
CLDN18.2HER2VEGF/VEGFRgastric cancertargeted therapy

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