Unraveling Persistent Genital Arousal Disorder-A Case Report on Innovative Therapeutic Approaches

Area of Science:

• Neuroscience
• Psychiatry
• Reproductive Medicine

Background:

• Persistent genital arousal disorder (PGAD) is a distressing condition with persistent, unwanted genital arousal unrelated to sexual desire.
• Symptoms can cause significant psychological distress, functional impairment, anxiety, depression, and social withdrawal.
• A patient's history included psychosocial factors like parental loss, miscarriages, and infertility-related distress.

Purpose of the Study:

• To present a case study of Persistent Genital Arousal Disorder (PGAD).
• To explore the multifactorial etiology of PGAD, including neurophysiological, reproductive, and psychological elements.
• To highlight the effectiveness of a comprehensive biopsychosocial treatment approach.

Main Methods:

• A case report of a woman in her 30s experiencing PGAD symptoms for 5 months.
• Diagnostic investigations included computed tomography, magnetic resonance imaging, electroencephalography, and pelvic imaging.
• Treatment involved a combination of pharmacotherapy (risperidone, sodium valproate, fluoxetine, clonazepam) and structured psychotherapy (relaxation, cognitive behavioral strategies).

Main Results:

• Computed tomography revealed a hyperdense focus in the right parietal lobe; other neuroimaging was unremarkable.
• Pelvic imaging showed a bicornuate uterus, and psychometric evaluation indicated moderate anxiety and depression.
• The multidisciplinary treatment led to significant clinical improvement within one week, with marked symptom reduction and improved functioning.

Conclusions:

• PGAD likely has a multifactorial etiology, integrating neurophysiological, reproductive, and psychological components.
• A comprehensive biopsychosocial approach is crucial for managing PGAD.
• Combined pharmacotherapy and psychotherapy can effectively alleviate PGAD symptoms and enhance quality of life.