COVID-19-Associated Cardiovascular Complications: A Narrative Literature Review

Aashna Lala1, Mykhailo Vysochyn2, Kateryna Shyshkova2

  • 1Clinical Sciences, Saint James School of Medicine, Park Ridge, USA.

Cureus
|April 20, 2026
PubMed

Insights

Coronavirus disease 2019 (COVID-19) is a systemic illness impacting the heart, causing complications like heart failure and arrhythmias. This review details cardiovascular issues in COVID-19 patients, aiding clinical recognition and management.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health crisis.
  • Initially viewed as respiratory, COVID-19 is now recognized as a systemic disease with significant cardiovascular implications.
  • Cardiovascular complications affect both patients with and without pre-existing heart conditions.

Purpose of the Study:

  • To review current evidence on cardiovascular complications in adult COVID-19 patients in the U.S.
  • To highlight differences in cardiovascular pathology between those with and without prior cardiovascular disease.
  • To discuss mechanisms, clinical features, diagnostics, and management of COVID-19-related cardiovascular issues.

Main Methods:

  • This study is a narrative review of existing literature.
  • Focuses on adult patients diagnosed with COVID-19 in the United States.
  • Synthesizes evidence regarding cardiovascular manifestations and outcomes.

Main Results:

  • COVID-19 can lead to myocardial injury, myocarditis, heart failure, arrhythmias, and thromboembolic events.
  • These complications increase disease severity and mortality.
  • Understanding these effects is crucial for patient management.

Conclusions:

  • COVID-19 poses substantial cardiovascular risks, necessitating increased clinical awareness.
  • Timely recognition and appropriate management are key to improving outcomes for affected patients.
  • Further research into mechanisms and treatments is warranted.

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