Related Experiment Video
Updated: Apr 21, 2026
Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
Evaluation of Role of Xylitol in Enhancing Dental Pulp Stem Cell Differentiation: A Clinical Study
Ahmed A Albariqi1, U Lavanya Neelima2, Sheetal Mujoo3
1Department of Periodontics and Community Dentistry, College of Dentistry, valid University, Abha, Saudi Arabia.
Purpose:
This study evaluates the impact of xylitol on the differentiation of dental pulp stem cells (DPSCs) in clinical settings, focusing on its potential as a bioactive agent to enhance regenerative outcomes.
Methods:
A controlled clinical study involving 40 patients assessed DPSCs isolated from extracted third molars. Patients were divided into two groups: xylitol-treated (Group A) and control (Group B). Differentiation was evaluated over 14 days using alkaline phosphatase (ALP) activity assays, immunohistochemistry, and mineralization analysis.
Results:
Xylitol treatment significantly enhanced odontogenic differentiation, evidenced by increased ALP activity (Group A: 78.6 ± 5.4 U/mg; Group B: 56.3 ± 4.7 U/mg, P < 0.05) and higher expression of odontogenic markers. Mineralization was markedly superior in the xylitol group (P < 0.05).
Conclusion:
Xylitol promotes DPSC differentiation, making it a promising adjunct for dental regenerative therapies. Further research into its molecular mechanisms is warranted.
