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Updated: Apr 21, 2026

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
Published on: November 21, 2018
Beyond barrier function: keratinocytes as orchestrators of humoral immunity
Chaohuan Guo1, George C Tsokos1
1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA.
Abstract:
The skin is a highly organized immune organ in which resident non-immune cells cooperate with immune cells to maintain host defense and shape systemic adaptive immunity. A recent study revealed that a keratinocyte-intrinsic farnesyl pyrophosphate-transient receptor potential vanilloid 3 pathway transforms epidermal stress into interleukin-6- and chemokine-dependent signals that promote dendritic cell migration, T follicular helper-cell expansion and germinal center activity, thereby amplifying humoral immunity and autoimmunity.
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