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Related Experiment Video

Updated: Apr 21, 2026

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor
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Association between end tidal capnography dynamics following vasopressor administration.

Banu Priya Raya Krishnamoorthy1, Xabier Jaureguibeitia2, Elisabete Aramendi2,3

  • 1Department of Emergency Medicine, The Ohio State University, Columbus, OH, United States.

Resuscitation Plus
|April 20, 2026
PubMed
Summary

End-tidal CO2 (EtCO2) changes after vasopressor administration in out-of-hospital cardiac arrest (OHCA) patients were analyzed. Increased EtCO2 proportional change and rise duration were associated with return of spontaneous circulation (ROSC).

Keywords:
Cardiac arrestEnd-tidal capnographyVasopressor

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Area of Science:

  • Cardiology
  • Emergency Medicine
  • Physiology

Background:

  • Dynamic changes in end-tidal CO2 (EtCO2) can indicate perfusion and ventilation status during cardiopulmonary resuscitation.
  • The impact of vasopressor administration on EtCO2 dynamics in out-of-hospital cardiac arrest (OHCA) remains largely uncharacterized.

Purpose of the Study:

  • To characterize EtCO2 variations following a single vasopressor dose in OHCA patients.
  • To investigate the relationship between EtCO2 morphology changes and return of spontaneous circulation (ROSC).

Main Methods:

  • Secondary analysis of the Pragmatic Airway Resuscitation Trial data.
  • Automated signal processing to summarize maximal EtCO2 values into one-minute epochs.
  • Analysis of EtCO2 morphology parameters including time to 15% rise, peak time, proportional change, and duration above 15%.

Main Results:

  • 517 OHCA patients receiving a single vasopressor dose were analyzed; 27% achieved ROSC.
  • Lag time and peak time to EtCO2 changes were not significantly different between ROSC and non-ROSC groups.
  • Greater proportional change in EtCO2 and longer duration of elevated EtCO2 were significantly associated with ROSC (p < 0.001).

Conclusions:

  • Following vasopressor administration, EtCO2 demonstrated increased proportional change and longer elevated durations in patients who achieved ROSC.
  • EtCO2 dynamics post-vasopressor administration may serve as a marker for resuscitation progress in OHCA.