Linkage Between miR-218-2 (rs11134527) Genetic Polymorphism and Breast Cancer Risk: A Case-Control Study in the
A M Shamim1, Aiman Hossan2, Md Shafiul Hossen3,4
1State University of Bangladesh South Purbachal, Kanchan Dhaka Bangladesh.
Health Science Reports
|April 20, 2026
Summary
The miR-218-2 rs11134527 A allele is linked to a higher breast cancer risk in Bangladeshi women. This finding suggests its potential use as a genetic biomarker for assessing breast cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Breast carcinoma development is influenced by genetic factors.
- MicroRNA (miRNA) gene subtypes are implicated in various cancers.
- The miR-218-2 gene, specifically the rs11134527 polymorphism, is investigated for its association with breast cancer risk.
Purpose of the Study:
- To explore the relationship between the miR-218-2 (rs11134527) single nucleotide polymorphism (SNP) and the risk of developing breast cancer.
- To evaluate the miR-218-2 rs11134527 polymorphism as a potential genetic biomarker for breast cancer susceptibility.
Main Methods:
- A case-control study involving 303 participants (158 breast cancer patients, 145 healthy controls).
- Genotyping of the miR-218-2 rs11134527 polymorphism was conducted using the T-ARMS-PCR technique.
- Statistical analyses, including binary logistic regression adjusted for age and BMI, were used to assess the association between the SNP and breast cancer risk.
Main Results:
- The AA genotype of miR-218-2 rs11134527 was significantly associated with an increased risk of breast cancer compared to the GG genotype (OR=2.48, p=0.025).
- Significant associations were also observed under recessive (OR=1.96, p=0.051) and allelic (A vs G: OR=1.59, p=0.026) models.
- Invasive ductal carcinoma was the most common histological type, and chemotherapy was the primary treatment modality.
Conclusions:
- The A allele of miR-218-2 rs11134527 is associated with an elevated risk of breast cancer in the Bangladeshi population.
- This genetic variant may serve as a population-specific biomarker for assessing breast cancer susceptibility.
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