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Demographic and Clinical Insights Into Pyoderma Gangrenosum: A Retrospective Cross-Sectional Study From a Tertiary
Mitra Mirzaei1, Alireza Jafarzadeh2, Sepideh Salehi3
1School of Medicine Iran University of Medical Sciences Tehran Iran.
Health Science Reports
|April 20, 2026
Summary
Pyoderma gangrenosum (PG) is linked to systemic diseases like inflammatory bowel disease (IBD) and cancer. Treatments like biologics and immunosuppressants showed the highest patient satisfaction, guiding future care.
Area of Science:
- Dermatology
- Internal Medicine
- Pathology
Background:
- Pyoderma gangrenosum (PG) is a rare, non-infectious inflammatory skin condition.
- PG is often associated with systemic disorders including inflammatory bowel disease (IBD), malignancies, and autoimmune conditions.
Purpose of the Study:
- To investigate demographic characteristics, comorbidities, differential diagnoses, and treatment outcomes in PG patients.
- To analyze patient satisfaction with various treatment regimens for histopathologically confirmed PG.
Main Methods:
- Retrospective cross-sectional study of 58 PG patients from 2018-2023.
- Data collected via medical records and phone interviews, including demographics, comorbidities, treatments, and satisfaction.
- Statistical analysis performed using SPSS version 26.
Main Results:
- 53.4% of patients were female, with a mean age of 55.88 years.
- Common comorbidities included IBD (29.3%), malignancy (15.5%), and rheumatoid arthritis (10.3%).
- Highest patient satisfaction reported with etanercept (100%), infliximab (83.3%), and methotrexate (60.0%).
Conclusions:
- PG frequently co-occurs with systemic diseases like IBD and malignancy, suggesting a syndromic relationship.
- Multidisciplinary evaluation is recommended for PG patients.
- Biologics and immunosuppressants demonstrate high treatment satisfaction, informing future clinical management and research.
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