Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

4.0K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
4.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

138
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
138
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

144
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
144

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invadopodia in cancer metastasis: dynamics, regulation, and targeted therapies.

Journal of translational medicine·2025
Same author

Mitochondria-derived vesicles: A promising and potential target for tumour therapy.

Clinical and translational medicine·2025
Same author

MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2019
Same author

Treatment of clinical T4 stage superior sulcus non-small cell lung cancer: a propensity-matched analysis of the surveillance, epidemiology, and end results database.

Bioscience reports·2019
Same author

Machine learning framework for assessment of microbial factory performance.

PloS one·2019
Same author

Low Pathogenic Avian Influenza A (H5N7) Virus Isolated from a Domestic Duck in Dongting Lake Wetland of China, 2016.

Virologica Sinica·2019

Related Experiment Video

Updated: Apr 21, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

26.4K

Exosomes as Emerging Nanocarriers for Targeted Cancer Therapy.

Yao Du1, Di Liu2, Jiaxing Liu1

  • 1Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, People's Republic of China.

International Journal of Nanomedicine
|April 20, 2026
PubMed
Summary

Exosomes, nanoscale vesicles, show promise as drug delivery carriers for cancer therapy due to their natural targeting and low immunogenicity. Engineering exosomes enhances their therapeutic payload delivery, though challenges in production and purification remain.

Keywords:
cancercargo loadingdrug delivery systemexosome

More Related Videos

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

1.0K
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

8.0K

Related Experiment Videos

Last Updated: Apr 21, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

26.4K
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

1.0K
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

8.0K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cell Biology

Background:

  • Exosomes are nanoscale vesicles secreted by cells, acting as natural carriers of bioactive molecules for intercellular communication.
  • Their inherent properties, including low immunogenicity and ability to cross biological barriers, make them ideal candidates for drug delivery systems.
  • Exosomes facilitate the transport of proteins, nucleic acids, and lipids, influencing physiological and pathophysiological processes.

Purpose of the Study:

  • To review the latest advancements in exosome-engineered targeted delivery platforms for cancer treatment.
  • To analyze existing exosome drug-loading technologies and their clinical application potential.
  • To identify key challenges hindering the clinical translation of exosome-mediated anti-tumor targeted therapies.

Main Methods:

  • Review of current literature on exosome biogenesis, isolation, and engineering techniques.
  • Analysis of exosome-based drug delivery systems and their payload encapsulation strategies.
  • Evaluation of exosome targeting mechanisms and their efficacy in preclinical and clinical studies.

Main Results:

  • Engineered exosomes can be precisely loaded with therapeutic payloads (nucleic acids, small molecule drugs) for targeted delivery.
  • Exosome-based delivery systems demonstrate enhanced tissue permeability and site-specific accumulation, particularly in tumor tissues.
  • Current limitations include low separation efficiency, high costs, and structural instability of exosomes.

Conclusions:

  • Exosomes hold significant potential as targeted delivery vehicles for cancer therapy, offering improved treatment outcomes.
  • Further research is needed to overcome challenges in exosome production, purification, and clinical translation.
  • Development of robust exosome-targeted delivery platforms is crucial for advancing exosome-mediated anti-tumor strategies.