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Diverticular disease increases the risk of acute myocardial infarction

Thanathip Suenghataiphorn1, Pojsakorn Danpanichkul2, Noppachai Siranart3

  • 1Department of Internal Medicine, Griffin Hospital, Derby, CT, United States.

Przeglad Gastroenterologiczny
|April 20, 2026
PubMed

Insights

Patients with diverticular disease face a 27% higher risk of acute myocardial infarction (AMI). Comprehensive cardiovascular care should include attention to gastrointestinal health, such as diverticular disease.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Diverticular disease is prevalent in patients with cardiovascular diseases.
  • A link exists between diverticular disease and adverse health outcomes.
  • The association between diverticular disease and acute myocardial infarction (AMI) risk is debated.

Purpose of the Study:

  • To systematically review and meta-analyze existing data.
  • To investigate the association between diverticular disease and AMI risk.

Main Methods:

  • Searched Medline and Embase databases from inception to August 2024.
  • Included studies comparing AMI incidence in cohorts with and without diverticular disease.
  • Combined effect sizes and 95% confidence intervals using the generic inverse variance method.

Main Results:

  • Included four studies with 898,397 participants (mean age 57 years, 43% males).
  • Patients with diverticular disease showed a 27% increased risk of AMI.
  • Pooled risk ratio (RR) was 1.27 (95% CI: 1.17, 1.37), with significant heterogeneity (I² = 83%).

Conclusions:

  • Diverticular disease is associated with an elevated risk of AMI.
  • Integrating gastrointestinal health, including diverticular disease management, is crucial for cardiovascular care.
Abstract

Keywords:
acute myocardial infarctiondiverticular diseasemeta-analysissystematic review

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