Related Experiment Video

Updated: Apr 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Prevalence of Vitamin D Deficiency and its Association with Disease Severity in Children Hospitalized with Acute

Maria Nicolae1, Cristina Maria Mihai1,2,3, Tatiana Chisnoiu2,3

  • 1Phd School of Medicine, Ovidius University of Constanta, Romania.

Current Health Sciences Journal
|April 20, 2026
PubMed

Insights

Vitamin D deficiency (VDD) in children is linked to more severe acute respiratory infections (ARI). Low vitamin D levels correlate with increased illness severity, fever, and longer hospital stays in pediatric patients.

Area of Science:

  • Pediatric Medicine
  • Infectious Diseases
  • Nutritional Science

Background:

  • Vitamin D deficiency (VDD) is a widespread issue in children.
  • VDD is suspected to influence the severity of acute respiratory infections (ARI).

Purpose of the Study:

  • To determine the prevalence of VDD in hospitalized pediatric patients with ARI.
  • To investigate the association between VDD and ARI severity and clinical outcomes.

Main Methods:

  • A 4-year prospective case-control study involving 400 pediatric patients (0-18 years) hospitalized with ARI.
  • Patients were divided into groups with low vitamin D (cases, n=200) and normal vitamin D (controls, n=200).
  • Clinical severity, inflammatory markers, fever, oxygen needs, and hospital stay duration were analyzed.

Main Results:

  • Low vitamin D levels were significantly linked to severe ARI (26.5% vs. 5.5%).
  • Patients with VDD had higher rates of fever (61.0% vs. 32.0%) and oxygen therapy needs (69.5% vs. 21.0%).
  • Higher C-reactive protein levels, clinical severity scores, and longer hospital stays were observed in the VDD group.

Conclusions:

  • Vitamin D deficiency is strongly associated with increased ARI severity in pediatric inpatients.
  • VDD correlates with adverse clinical outcomes, including prolonged hospitalization.
Abstract

Keywords:
Vitamin D deficiencyacute respiratory infectionsdisease severitypediatrics

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.2K
Assessing Respiratory Immune Responses to Haemophilus Influenzae06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

2.7K

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
695
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.3K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.7K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
1.1K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
9.1K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
2.1K