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Updated: Apr 26, 2026

Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
In dogs undergoing extrahepatic portosystemic shunt attenuation, does pretreatment with levetiracetam reduce
Abstract:
PICO question In dogs undergoing surgical attenuation of a congenital extrahepatic portosystemic shunt, does pretreatment with levetiracetam reduce the incidence of post attenuation seizures? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Four papers were critically reviewed. All were retrospective cohort studies Strength of evidence Moderate Outcomes reported In one paper levetiracetam was found to reduce the risk of post-attenuation seizures. In the remaining three papers no difference was found between the frequency of post-attenuation seizures and the use of levetiracetam Conclusion That prophylactic levetiracetam is not indicated for the use of preventing post-attenuation seizures in dogs surgically treated for extrahepatic portosystemic shunts.
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