Does trazodone reduce anaesthetic agent requirement in dogs?

PICO question In dogs undergoing anaesthesia, does the use of oral trazodone given 2 hours before induction of anaesthesia reduce injectable or inhalant anaesthetic agent requirements? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Two randomised controlled trials were critically appraised Strength of evidence Moderate Outcomes reported Trazodone was shown to have a significant isoflurane minimum alveolar concentration (MAC) sparing effect for isoflurane. There is also evidence to suggest trazodone has a similar effect on the cardiovascular system as acepromazine Conclusion Trazodone should be considered as part of a multimodal approach to anaesthesia in dogs to reduce the injectable and inhalant anaesthetic agent requirements.