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Related Experiment Video

Updated: Jul 3, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell

Rebecca Herzog^1,2, Lisa Daniel-Fischer^1,2, Fabian Eibensteiner^1,2,3

¹Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Kidney International Reports

|April 20, 2026

Summary

This summary is machine-generated.

Peritoneal dialysis (PD) patients with high inflammation face increased infection risk. Supplementing PD fluid with alanyl-glutamine (AlaGln) improved immune function in these patients, potentially preventing infections.

Keywords:

amino acid metabolism glucose metabolism glutamine immune paralysis peritoneal inflammation peritonitis

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Area of Science:

Nephrology
Immunology
Metabolism

Background:

Peritoneal dialysis (PD) is a common home dialysis therapy.
High-glucose PD fluids can cause inflammation and infection, limiting treatment effectiveness.

Purpose of the Study:

To investigate the interplay between peritoneal cell immune function, inflammation, and glucose metabolism in PD patients.
To identify potential therapeutic targets for improving PD outcomes.

Main Methods:

Prospective cohort study of 117 PD patients with longitudinal follow-up.
Assessed peritoneal inflammation (IL-6) and immune cell function (cytokine release).
Performed proteomic and metabolomic profiling of peritoneal effluents; conducted ex vivo experiments.

Main Results:

Peritoneal inflammation correlated with impaired immune function and increased peritonitis risk (HR: 3.8).
Patients with high inflammation showed altered glucose and amino acid metabolism.
Alanyl-glutamine (AlaGln) supplementation restored immune function in inflamed patients.

Conclusions:

First longitudinal evidence linking PD immunometabolism to inflammation, impaired immunity, and infection.
Metabolic interventions targeting immune function offer a novel approach to improve PD patient outcomes.