Prevalence of DSPN and Its Risk Factors Among Type 2 Diabetes Patients Attending Xuhang Community Health Service...

This study aimed to investigate the prevalence of distal symmetrical polyneuropathy (DSPN) among Type 2 diabetes mellitus (T2DM) patients in the suburbs of Shanghai, China, and identify associated risk factors.

The screening process consisted of information registration, clinical consultation, and laboratory testing, which included hematological parameters, hepatic and renal function profiles, metabolic markers (glycemic control and lipid profiles), tumor biomarkers, and urinalysis. Additionally, the process involved screening tests for peripheral neuropathy, skin condition assessment, evaluation of toe deformities, and lower extremity vascular examination. The results were initially analyzed using univariate analysis, and variables with statistical significance were subsequently incorporated into logistic regression modeling to evaluate the associated risk factors.

The prevalence of DSPN was 45.53%. Univariate analysis found that diabetes duration, cardiovascular disease (CVD), dry skin, callus, dorsalis pedis artery pulsation (DPAP), posterior tibial artery pulsation (PTAP), popliteal artery pulsation (PP), age, red blood cell (RBC), low-density lipoprotein (LDL), and creatinine (Cr) are statistically significant. The results of the logistic regression showed that age, dry skin, callus, and Cr are statistically significant among the risk factors for DSPN.

T2DM patients in suburban areas exhibit a high prevalence of DSPN, with age, dry skin, callus, and elevated Cr levels serving as major risk factors for its development.