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Related Experiment Videos

Propranolol withdrawal in angina pectoris: a prospective study.

M G Myers, M R Freeman, Z A Juma

    American Heart Journal
    |March 1, 1979
    PubMed
    Summary

    Abruptly stopping propranolol in angina patients did not lead to a rebound withdrawal reaction. Most patients experienced uneventful recovery, with few complications post-cessation.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Propranolol is a beta-blocker commonly used for angina pectoris.
    • Concerns exist regarding potential adverse effects upon abrupt discontinuation of beta-blockers, known as rebound phenomena.

    Purpose of the Study:

    • To investigate the occurrence of rebound propranolol withdrawal reactions in patients with angina pectoris undergoing coronary arteriography.
    • To assess the safety of abrupt propranolol cessation prior to cardiac procedures.

    Main Methods:

    • Prospective study of 100 consecutive angina patients undergoing elective coronary arteriography.
    • Patients had propranolol therapy abruptly discontinued 24-144 hours before the procedure.
    • Clinical outcomes, including chest pain and myocardial infarction, were monitored.

    Main Results:

    • Only a small number of patients experienced minor chest pain increases or non-transmural myocardial infarctions prior to cessation.
    • The incidence of complications in the post-withdrawal period was similar to the pre-cessation period.
    • No significant rebound propranolol withdrawal reaction was observed in the majority of patients.

    Conclusions:

    • The findings do not support the concept of a rebound propranolol withdrawal reaction in this patient cohort.
    • Abrupt discontinuation of propranolol appears safe in patients with angina undergoing coronary arteriography, provided careful monitoring.
    • Further research may be warranted to define specific patient subgroups who might be at higher risk.

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