Obstructive sleep apnea contributes to coronary artery disease development and poor prognosis

To explore the correlation between obstructive sleep apnea (OSA) and the incidence of coronary heart disease (CHD), as well as the impact of OSA severity on the short-term outcomes of CHD patients.

A retrospective analysis was conducted on 78 CHD patients admitted to Zhejiang Provincial People's Hospital from January 2022 to December 2024, with another 78 subjects who underwent health checkups in the same hospital during the same period enrolled as the control group. The prevalence of OSA and baseline data were compared between the two groups. Meanwhile, CHD patients were divided into the mild-to-moderate (n = 26) and severe (n = 19) OSA groups according to OSA severity. Baseline data of patients in different subgroups were compared, and all patients were followed up. The incidence of adverse cardiovascular events was recorded and analyzed.

The CHD group had higher incidences of OSA, hypertension, dyslipidemia and diabetes compared to the control group (all P < 0.05). Multivariate analysis identified these factors as independent risk factors for CHD. A predictive model constructed based on these factors showed good performance with an AUC of 0.638. Further analysis revealed that patients with severe OSA had higher levels of peripheral hemoglobin and IL-6, higher incidence of coagulation dysfunction and diabetes mellitus than those with mild-to-moderate OSA (all P < 0.05).

OSA is closely associated with the occurrence of CHD, and the predictive model established by combining OSA with other baseline data has favorable predictive efficacy for CHD. In addition, OSA severity exerts a notable impact on the prognosis of CHD patients.