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Updated: Apr 21, 2026

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Published on: October 1, 2019
Cerebral Hemodynamics Are Related to Cortical Brain Morphology in Heart Failure with Reduced Ejection Fraction
Cameron J Morse1, Adam M S Luchkanych1, Natasha G Boyes2
1Department of Biomedical Sciences, Western College of Veterinary Medicine, The University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Abstract:
This study aimed to investigate whether reduced cerebral blood flow is associated with cortical brain remodelling in patients with heart failure with reduced ejection fraction (HFrEF). Further, to assess whether these changes occur independently of decreased cardiac output and correlate with alternative markers of HFrEF severity. The findings suggest that brain remodelling in HFrEF can occur independently of reduced cardiac output, highlighting the importance of other pathophysiological factors. A nuanced understanding of these mechanisms could inform improved diagnostic and therapeutic strategies targeting cardiocerebral interactions.
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