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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Apr 21, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

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Smart Magnetic Nanozyme for Multimodal Dynamic Regulation to Reverse Multidrug Resistance in Breast Cancer.

Jinzhao He1, Senyi Gong1, Yu Liu1

  • 1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.

Molecular Pharmaceutics
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel nanozyme, HADAF, to combat multidrug resistance (MDR) in breast cancer by targeting TRPA1. This smart therapy effectively reversed drug resistance, showing significant potential for cancer treatment.

Keywords:
magneto-mechanical therapymultidrug resistancenanozymephotodynamic therapyredox homeostasis

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Intratumoral redox homeostasis contributes to multidrug resistance (MDR), reducing the efficacy of chemotherapy drugs like doxorubicin (DOX).
  • Overexpression of TRPA1, a redox homeostasis regulator, is linked to drug resistance in breast cancer patients.

Purpose of the Study:

  • To develop a targeted therapeutic strategy to overcome redox homeostasis-driven MDR in breast cancer.
  • To design and evaluate a smart magnetic nanozyme capable of reversing MDR.

Main Methods:

  • Transcriptome analysis of 216 breast cancer patients to identify TRPA1 association with drug resistance.
  • Design of HADAF nanozyme (HA@Anti-TRPA1@DOX@Au@Fe3O4) integrating gold-iron oxide nanosheets, DOX, anti-TRPA1 oligonucleotides, and hyaluronic acid.
  • Spatiotemporal control of HADAF using low-frequency vibrational magnetic field (VMF) and near-infrared (NIR) laser irradiation.

Main Results:

  • HADAF effectively inhibited the TRPA1/PI3K/mTOR/MCL-1 signaling pathway, inducing apoptosis and ferroptosis.
  • Achieved a 90% inhibition rate in MCF-7/ADR cells.
  • Reduced the IC50 of DOX by 87.7-fold compared to free DOX in combination therapy.

Conclusions:

  • The multimodal nanozyme HADAF offers a novel strategy to target redox homeostasis and overcome MDR in cancer therapy.
  • HADAF demonstrates significant potential in enhancing the efficacy of doxorubicin chemotherapy by reversing multidrug resistance.