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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Apr 21, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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Pustular Mycosis Fungoides Triggered by Systemic Interferon-γ.

Mai Nishida1,2, Takatoshi Shimauchi1, Yuto Ishikawa2

  • 1Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

The Journal of Dermatology
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Pustular mycosis fungoides (pMF) is a rare skin condition. Systemic interferon-gamma triggered a pustular eruption in a patient with mycosis fungoides, suggesting it can act as a pMF trigger.

Keywords:
IFN‐γIL‐8generalized pustular psoriasispustular mycosis fungoides

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Pustular mycosis fungoides (pMF) is a rare variant of mycosis fungoides (MF).
  • pMF presents with clinical and histopathological pustule formation.
  • The pathogenesis of pMF is not fully understood.

Purpose of the Study:

  • To report a case of pMF triggered by systemic interferon-gamma (IFN-γ).
  • To investigate the cytokine profile associated with IFN-γ-induced pMF.

Main Methods:

  • Case report of a 71-year-old Japanese woman with MF.
  • Clinical presentation, histopathological examination, and cytokine analysis (IL-8, IL-18, IL-23, IL-6) were performed.
  • Treatment involved discontinuation of IFN-γ and antibiotic administration.

Main Results:

  • The patient developed a generalized pustular eruption after IFN-γ administration.
  • Histology showed spongiform pustules and CD30+ atypical lymphoid cells.
  • Elevated serum IL-8, IL-18, IL-23, and IL-6 normalized upon remission.
  • Pustules resolved rapidly after IFN-γ discontinuation.

Conclusions:

  • Systemic IFN-γ can potentially trigger pustular mycosis fungoides.
  • The IL-23/IL-17/IL-8 axis may play a critical role in pMF pathogenesis.
  • This case highlights a novel therapeutic consideration and sheds light on pMF pathophysiology.