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Analysis of Prevalence and Mortality Among Neonates and Children With Intestinal Atresia: A Multinational Study,

Angie Carreño1, Maria Paula Aguilera2, Lina Ibañez3

  • 1Birth Defect Surveillance Program, Faculty of Health Sciences, Pontificia Universidad Javeriana, Cali, Colombia.

Birth Defects Research
|April 20, 2026
PubMed

Insights

Small intestinal atresia (SIA) affects 2.1 in 10,000 births globally, with significant geographical variations. This study analyzed SIA prevalence and mortality over 41 years, highlighting the need for further research into trends and treatment impacts.

Area of Science:

  • Pediatric Surgery
  • Neonatal Care
  • Birth Defects Research

Background:

  • Small intestinal atresia (SIA) is a congenital condition causing obstruction in the small intestine.
  • SIA severity varies, impacting newborns' digestive systems.
  • Understanding SIA prevalence and mortality is crucial for neonatal care.

Purpose of the Study:

  • To determine the global prevalence of small intestinal atresia (SIA).
  • To analyze mortality rates associated with SIA.
  • To identify geographical variations in SIA occurrence using ICBDSR data.

Main Methods:

  • Data collected from 25 International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) programs (1974-2015).
  • Prevalence calculated as SIA cases per 10,000 births.
  • Mortality analyzed using Kaplan-Meier survival analysis.

Main Results:

  • Overall SIA prevalence was 2.1 per 10,000 births.
  • Highest prevalence observed in Iran (11.5/10,000), lowest in Mexico-Nuevo Leon (0.5/10,000).
  • First-year mortality was 4.3%; most deaths occurred within the first week of life.

Conclusions:

  • SIA prevalence varies geographically, with an overall rate of 2.1 per 10,000 births over 41 years.
  • Further research is recommended to investigate trends and the impact of early diagnosis and treatment on SIA mortality.
Abstract

Keywords:
epidemiologymortalitysmall intestinal atresiasurveillance programssurveillance registries

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