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18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity.

Yao Lu1, Lin Li, Liu Xiao

  • 1Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan Province, P.R. China.

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|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Papillary renal neoplasm with reverse polarity (PRNRP) is a rare kidney tumor. Imaging showed a left renal pelvis nodule with high 18F-FDG uptake but no 68Ga-FAPI-04 uptake, confirmed by pathology.

Keywords:
FAPIFDGPET/CTpapillary renal neoplasm with reverse polarity

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Area of Science:

  • Nephrology
  • Oncology
  • Radiology

Background:

  • Papillary renal neoplasm with reverse polarity (PRNRP) is an exceptionally rare renal tumor.
  • Accurate diagnosis of PRNRP can be challenging due to its rarity.

Purpose of the Study:

  • To describe the imaging characteristics of PRNRP.
  • To highlight the utility of combined PET/CT imaging in diagnosing rare renal neoplasms.

Main Methods:

  • Case report of a 75-year-old woman with PRNRP.
  • Utilized 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT for imaging.
  • Confirmed diagnosis with postsurgical histopathology.

Main Results:

  • The PRNRP presented as a soft-tissue nodule in the left renal pelvis.
  • The lesion demonstrated intense 18F-FDG uptake (SUVmax: 20.8).
  • No significant uptake of 68Ga-FAPI-04 was observed.

Conclusions:

  • Combined 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT can provide valuable diagnostic information for PRNRP.
  • Distinctive imaging features, including high FDG avidity and lack of FAPI uptake, may aid in the preoperative diagnosis of this rare entity.