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A novel 14-deoxy-12-hydroxyandrographolide analogue promotes apoptosis in colorectal cancer through ROS-dependent

Somrudee Reabroi1,2, Teerapich Kasemsuk3, Rungnapha Saeeng4,5

  • 1Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. somrudee.rea@mahidol.ac.th.

Discover Oncology
|April 20, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
14-deoxy-12-hydroxyandrographolide analogueApoptosisColorectal cancerER stressROS

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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