Related Experiment Video

Updated: Apr 22, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

11.4K

Proteogenomics: decoding cancer in multiple dimensions

Qian Liu1, Yimin Chen2,3, Hu Zhou4,5,6

  • 1Analytical Research Center for Organic and Biological Molecules, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. liuqian@simm.ac.cn.

Medscience
|April 20, 2026
PubMed

Insights

Precision oncology faces challenges linking genomics to protein function. Proteogenomics, integrating mass spectrometry-based proteomics with other

Area of Science:

  • Proteomics and Genomics
  • Cancer Biology
  • Mass Spectrometry

Background:

  • Genomic analyses in precision oncology struggle to predict protein expression and function, crucial for targeted therapies.
  • Precise quantification of proteins and post-translational modifications (PTMs) is needed to bridge this gap.
  • Mass spectrometry (MS)-based proteomics offers large-scale, quantitative characterization of proteins and PTMs in tumors.

Purpose of the Study:

  • To review advancements in MS-based proteomics for cancer research.
  • To highlight key discoveries in cancer proteogenomics.
  • To discuss the potential of proteogenomics in understanding cancer complexity.

Main Methods:

  • Integration of proteomic data (including PTMs) with genomic, epigenomic, and transcriptomic information.
  • Utilizing mass spectrometry for large-scale, quantitative protein and PTM characterization.
  • Reviewing recent literature on MS-based proteomics and cancer proteogenomics.

Main Results:

  • MS-based proteomics enables quantitative characterization of proteins and PTMs in tumor tissues.
  • Proteogenomics integrates multi-omics data for a deeper understanding of cancer biology.
  • Recent advancements facilitate linking genomic aberrations to cancer phenotypes.

Conclusions:

  • Proteogenomics offers a comprehensive approach to decoding cancer complexity at multiple biological levels.
  • This integrated field has transformative potential for precision oncology.
  • Advancements in MS-based proteomics are key drivers of progress in cancer proteogenomics.
Keywords:
cancermulti-omicsprecision oncologyproteogenomicsproteomics

More Related Videos

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

20.1K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

1.1K

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

5.5K
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

2.6K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.6K
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.4K