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Prepregnancy Care and Counseling: A Review
Kylie M Cooper1, Linda M Szymanski1, Paru S David2
1Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
JAMA
|April 20, 2026
Summary
Optimize maternal and infant health with prepregnancy care. Key interventions include folic acid, substance cessation, immunizations, and screenings to reduce risks and improve outcomes.
Area of Science:
- Obstetrics and Gynecology
- Public Health
- Preventive Medicine
Background:
- 66.4% of US reproductive-aged women have modifiable risk factors for adverse pregnancy outcomes.
- Prepregnancy care is crucial for optimizing maternal and infant health.
- Unintended pregnancies are linked to higher risks of postpartum depression, preterm birth, and low infant birth weight.
Purpose of the Study:
- To highlight the importance of prepregnancy care and counseling.
- To outline key interventions for individuals desiring pregnancy.
- To emphasize the role of primary care in optimizing pregnancy outcomes.
Main Methods:
- Review of interventions including folic acid supplementation, cessation of tobacco, alcohol, cannabis, and opioids.
- Discussion of immunizations against hepatitis B virus, varicella, and rubella.
- Emphasis on screening for syphilis and HIV, chronic disease management, and weight management.
Main Results:
- Folic acid use reduces fetal neural tube defects (RR, 0.67).
- Tobacco smoking increases risks of stillbirth, neonatal, and perinatal death.
- Prepregnancy interventions decrease fetal and neonatal infection and mortality.
- Optimizing chronic conditions like diabetes and cardiovascular disease before conception reduces risks.
Conclusions:
- Prepregnancy counseling and care significantly reduce maternal and neonatal morbidity and mortality.
- Primary care plays a vital role in discussing reproductive goals, immunizations, screenings, and risk-reducing interventions.
- Proactive health management before conception is essential for positive pregnancy outcomes.
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