Related Experiment Video
Updated: Apr 22, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
Objectively Measured Daytime Napping Patterns and All-Cause Mortality in Older Adults
Chenlu Gao1,2,3, Ruixue Cai1,2, Xi Zheng1
1Department of Anesthesiology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Longer and more frequent daytime naps in older adults are linked to increased mortality risk. Morning naps, in particular, show a higher risk, suggesting potential for early health monitoring using wearable devices.
Area of Science:
- Gerontology
- Epidemiology
- Sleep Science
Background:
- Daytime napping is prevalent in older adults, but objective data on nap patterns and mortality risk is scarce.
- Previous research relied on self-reported napping, potentially introducing bias.
- Specific nap characteristics like timing and duration variability remain understudied in relation to mortality.
Purpose of the Study:
- To investigate the association between objective daytime nap patterns (duration, frequency, variability, timing) and all-cause mortality in older adults.
- To utilize actigraphy data for precise measurement of napping behaviors.
- To identify potential early indicators of mortality risk through sleep pattern analysis.
Main Methods:
- Prospective cohort study involving community-dwelling older adults (aged 56+) from the Rush Memory and Aging Project.
- Actigraphy devices were used to objectively assess daytime napping (9 am-7 pm) for up to 14 days.
- Cox proportional hazards regression models analyzed associations between baseline nap characteristics and subsequent all-cause mortality, adjusting for covariates.
Main Results:
- Longer daytime nap duration (per 1-hour increase) was associated with a 13% increased mortality risk (AHR=1.13).
- Higher nap frequency (per additional daily nap) was linked to a 7% increased mortality risk (AHR=1.07).
- Morning nappers exhibited a 30% higher mortality risk compared to early afternoon nappers (AHR=1.30). Nap duration variability was not significantly associated with mortality.
Conclusions:
- Objective measures reveal that longer, more frequent daytime naps, particularly those occurring in the morning, are associated with increased all-cause mortality in older adults.
- These findings highlight the potential of wearable device-based nap assessment for early identification of health risks.
- Integrating objective sleep data into clinical and public health practices could offer new avenues for proactive health management.
Related Concept Videos
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Pharmacodynamics in Geriatric Patients: Effects of Age
Narcolepsy
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

