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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

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A Stable Metal-Polyphenol Network-Functionalized Black Phosphorus Nanoplatform for Multidrug-Loading and Controllable

Tingxu Guo¹, Yawen Huang¹, Wanmeng Liu¹

¹College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, China.

Small (Weinheim an Der Bergstrasse, Germany)

|April 20, 2026

Summary

Researchers developed a versatile nanocarrier, black phosphorus nanosheets modified with a metal-polyphenol network (BP@MPN), for efficient drug delivery. This platform shows broad drug compatibility and potential for synergistic chemo-photothermal cancer therapy.

Keywords:

black phosphorus controlled release drug delivery metal‐polyphenol network nanocarrier

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Designing universal nanocarriers with broad drug compatibility, high loading efficiency, and controlled release is challenging.
Existing nanocarriers often face limitations in stability and versatility for diverse therapeutic agents.

Purpose of the Study:

To develop a versatile nanocarrier platform (BP@MPN) with enhanced stability and broad drug compatibility.
To evaluate the loading efficiency, biocompatibility, and therapeutic efficacy of the BP@MPN platform.

Main Methods:

Fabrication of black phosphorus nanosheets modified with a metal-polyphenol network (BP@MPN).
Evaluation of drug loading capacity for various therapeutic agents (small molecules, proteins, inorganic nanostructures, metal ions).
In vitro and in vivo studies using a B16F10 tumor model for chemo-photothermal therapy.

Main Results:

BP@MPN demonstrated superior loading performance for a wide range of drugs due to diverse non-covalent interactions.
Quartz crystal microbalance analysis confirmed strong drug-carrier interactions enhancing loading efficiency.
BP@MPN exhibited excellent biocompatibility and hemocompatibility, with potent chemo-photothermal synergistic therapy (TGI = 88.5%) in a tumor model.

Conclusions:

BP@MPN serves as a promising, broadly applicable nanocarrier platform for controlled drug delivery.
The multifunctional interface of BP@MPN enables efficient loading and controlled release of diverse therapeutic agents.
BP@MPN holds potential for advanced nanomedicine, particularly in synergistic cancer therapy with minimal toxicity.