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Platelet-derived TGF-β1 and Treg maintenance in a murine model of ITP

Jasimuddin Ahamed1

  • 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.

Blood
|April 20, 2026
PubMed

Studies suggest that platelet-derived transforming growth factor (TGF)-β1 is critical to immune thrombocytopenia tolerance via regulatory T-cell (Treg) modulation, but their implausibly high TGF-β1 levels likely reflect ex vivo artifacts. We could not confirm platelet-derived TGF-β1-driven Treg deficiency using knockout mice; remission maintenance likely involves extra-platelet TGF-β1 sources.

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