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Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term,
Xinyue Zhang1,2, Ziwen Wang1,2, Mingsheng Sun1,2
1School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Plos One
|April 20, 2026
Summary
This study investigates the long-term effects of acupuncture on cognitive function in individuals with amnestic mild cognitive impairment (aMCI). Findings will inform clinical management strategies for this neurodegenerative condition.
Area of Science:
- Neuroscience
- Gerontology
- Integrative Medicine
Background:
- Amnestic mild cognitive impairment (aMCI) is a prevalent neurodegenerative condition in older adults.
- Previous research suggests acupuncture may improve cognitive function in aMCI patients, but long-term effects are unknown.
Purpose of the Study:
- To evaluate the long-term efficacy of acupuncture for managing aMCI.
- To provide evidence-based recommendations for clinical practice.
Main Methods:
- A multicenter, single-blinded, randomized controlled trial (RCT) involving 166 aMCI patients.
- Comparison between an acupuncture group (AG) and a sham acupuncture group (SA) over 60 weeks.
- Primary outcomes measured by Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) scores at weeks 12 and 60, analyzed using Generalized Estimating Equations (GEE).
Main Results:
- Data collection and analysis are ongoing.
- Anticipated to reveal significant differences in cognitive function changes between groups.
Conclusions:
- This RCT protocol is designed to rigorously assess acupuncture's long-term impact on aMCI.
- Expected to yield valuable insights for the clinical management of aMCI.
