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A standardized workflow for kinetic metabolic model curation and dissemination
Margaret Cook1, Stella Anastasakis2, Adel Heydarabadipour3
1Molecular Engineering and Sciences Institute, University of Washington, Seattle, Washington, United States of America.
Plos Computational Biology
|April 20, 2026
Summary
This study introduces a workflow for creating reproducible kinetic metabolic models. The method ensures clear documentation, annotation, and visualization for systems biology applications.
Area of Science:
- Systems Biology
- Metabolic Engineering
- Synthetic Biology
Background:
- Kinetic metabolic models are crucial for understanding cellular metabolism.
- Reproducibility and utility depend on documentation, annotation, and visualization.
Purpose of the Study:
- To present a workflow for building, annotating, visualizing, and sharing kinetic metabolic models.
- To enhance the reproducibility, interoperability, and accessibility of these models.
Main Methods:
- Integration of community standards.
- Utilization of open-source tools.
- Development of a standardized workflow.
Main Results:
- A procedure for creating reusable and well-documented kinetic models.
- Improved accessibility and interoperability of metabolic models.
Conclusions:
- The workflow advances the utility of kinetic metabolic models in research.
- Standardized practices are essential for robust metabolic modeling.
