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Single-nucleus and spatial transcriptomic analyses reveal intra-tissue heterogeneity of PNPLA3

Bingqing Yang1, Yuanying Zhao2, Qi Wang1

  • 1Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Journal of Hepatology
|April 20, 2026
PubMed
Abstract

No abstract available in PubMed .

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The Nucleolus02:55

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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

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