Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

1.1K
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
1.1K
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

4.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.8K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

1.1K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.1K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

146
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
146
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

226
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
226
Atomic Absorption Spectroscopy: Atomization Methods01:25

Atomic Absorption Spectroscopy: Atomization Methods

1.8K
Atomic Absorption Spectroscopy (AAS) atomizes samples through flame atomization or electrothermal atomization. Flame atomization typically involves a nebulizer and spray chamber assembly to combine the sample with a fuel–oxidant mixture, creating a fine aerosol mist that enters a burner. Typically, the fuel and oxidant are combined in an approximately stoichiometric ratio. However, for atoms that are easily oxidized, a fuel-rich mixture may be more advantageous. Only about 5% of the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of Dry Powder Inhalers: 2. The Impact of Suboptimal Peak Inspiratory Flow Rates on Bronchodilation in Patients with Obstructive Lung Diseases.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same author

Design of Dry Powder Inhalers: 1. Does Size Matter?

Journal of aerosol medicine and pulmonary drug delivery·2026
Same author

Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCO<sub>3</sub><sup>-</sup> Flux in Cystic Fibrosis Airway Epithelia.

ACS chemical biology·2025
Same author

Molecular prosthetics and CFTR modulators additively increase secretory HCO<sub>3</sub> <sup>-</sup> flux in cystic fibrosis airway epithelia.

bioRxiv : the preprint server for biology·2025
Same author

Design of dry powder inhalers to improve patient outcomes: it's not just about the device.

Expert opinion on drug delivery·2024
Same author

Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations.

Pharmaceutics·2021
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies
08:33

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies

Published on: April 12, 2022

4.7K

Reimagining carrier-based formulations for inhalation: Respirable agglomerates.

Jeffry G Weers1, Thomas E Tarara2, Danforth P Miller2

  • 1Independent Consultant, Bainbridge Island, WA, United States.

Journal of Pharmaceutical Sciences
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

New nanostructured carrier particles improve lung delivery of drugs by forming respirable agglomerates. This approach enhances dose consistency and reduces flow rate dependency for inhaled medications.

Keywords:
Aerosphere®Co-formulation effectsFlow rate dependenceInteractive mixturesNanoleucineOropharyngeal filteringPulmosphere™Small airways deliveryTechnosphere®

More Related Videos

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

3.4K
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

42.0K

Related Experiment Videos

Last Updated: Apr 22, 2026

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies
08:33

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies

Published on: April 12, 2022

4.7K
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

3.4K
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

42.0K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Nanotechnology

Background:

  • Traditional carrier-based formulations use coarse lactose particles, leading to suboptimal lung delivery.
  • Fine drug particles exhibit strong cohesive forces, complicating formulation.
  • Conventional carriers cause issues like oropharyngeal filtering and flow rate dependency.

Purpose of the Study:

  • To explore nanostructured carrier particles as an alternative to coarse carriers.
  • To improve lung targeting, dose consistency, and reduce flow rate sensitivity.
  • To enable stable suspensions for metered dose inhalers.

Main Methods:

  • Development of carrier-based formulations using micronized or nanosized drug particles and nanostructured carriers.
  • Characterization of respirable agglomerate formation.
  • Assessment of lung delivery efficiency and dose consistency.

Main Results:

  • Nanostructured carriers form respirable agglomerates with drug particles.
  • These agglomerates significantly improve lung targeting and dose consistency.
  • Reduced sensitivity to inhalation flow rate was observed.

Conclusions:

  • Nanostructured carrier particles offer a superior alternative to conventional coarse carriers.
  • Respirable agglomerates enhance inhaled drug delivery performance.
  • This approach holds promise for improved metered dose inhaler formulations.