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Updated: Apr 22, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Chemotherapy as a salvage strategy after immunotherapy failure in advanced hepatocellular carcinoma: A case series
Yasemin Evlendi1, Gonca Eldem2, Sevtap Arslan Sarıkaya2
1Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Abstract:
The role of systemic chemotherapy after immunotherapy failure in advanced hepatocellular carcinoma (HCC) remains poorly defined. We describe five patients with advanced HCC who progressed on immune checkpoint inhibitor-based therapy and subsequently received cytotoxic chemotherapy. Gemcitabine-, fluorouracil-, and platinum-based chemotherapy regimens, including hepatic arterial infusion chemotherapy in one patient, were administered. Three patients achieved a partial radiologic response, whereas two showed early disease progression. These descriptive observations suggest that, in carefully selected patients with preserved liver function and good performance status, chemotherapy may be associated with radiologic disease control after immunotherapy failure.
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