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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
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MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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Automated leucocyte VCS parameter profiling for differentiating SARS-CoV-2 and dengue infections: A comparative

R Jayashree1, M Suchitra Shenoy2, Sridevi Hanaganahalli Basavaiah3

  • 1Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

Indian Journal of Medical Microbiology
|April 20, 2026
PubMed
Summary

This study compared leukocyte volume, conductivity, and scatter (VCS) parameters in COVID-19 and dengue infections. While distinct patterns emerged, no single VCS parameter reliably predicted disease severity for either infection.

Keywords:
AutomatedCOVID-19ConductivityDengueVCS technology

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Diagnostic Technology

Background:

  • Automated hematology analyzers utilize volume, conductivity, and scatter (VCS) technology to assess leukocyte characteristics.
  • COVID-19 and dengue are significant global and endemic infections, respectively, with distinct clinical presentations.
  • Understanding leukocyte responses in these infections is crucial for diagnosis and management.

Purpose of the Study:

  • To comparatively analyze leukocyte-VCS parameters in patients with SARS-CoV-2 (COVID-19) and dengue infections.
  • To evaluate the potential of leukocyte-VCS parameters as a diagnostic tool for differentiating between these two infections.

Main Methods:

  • A retrospective study involving 200 patients (100 COVID-19, 100 dengue) over six months.
  • Complete blood counts (CBC) with VCS parameters were analyzed using Beckman Coulter DxH 800/900 analyzers.
  • VCS properties of neutrophils, lymphocytes, eosinophils, and monocytes were compared between the two groups.

Main Results:

  • COVID-19 cases showed higher white blood cell (WBC) count, absolute neutrophil count, and platelet count.
  • Dengue cases presented with thrombocytopenia, higher absolute lymphocyte and monocyte counts, and lower WBC count.
  • Distinct VCS parameter profiles were observed: higher neutrophil volume/conductivity in COVID-19, higher neutrophil scatter in dengue, and higher monocyte conductivity in dengue.

Conclusions:

  • Significant differences in leukocyte parameters and VCS properties exist between COVID-19 and dengue infections.
  • Individual VCS parameters showed limited predictive accuracy for disease severity.
  • Future research could explore combined parameters and modeling for improved predictive capabilities.