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Obtaining Human Microglia from Adult Human Brain Tissue
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Microglia in human models of development and disease: are we prioritising model 'success' over biological truth?

M Barresi1, R Ravi Prasad1, A Quigley2

  • 1School of Health and Biomedical Sciences, RMIT University, Bundoora 3085, VIC, Australia.

Neuroscience
|April 20, 2026
PubMed
Abstract

No abstract available in PubMed .

Insights

Induced pluripotent stem cells (iPSCs) can be differentiated into microglia, a type of brain immune cell. This research explores the epigenomic changes during this cell lineage development, offering insights into brain organoid physiology.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Microglia are crucial for brain development and function.
  • Induced pluripotent stem cells (iPSCs) offer a model for studying cell differentiation.
  • Understanding microglia development is key to neurodevelopmental and neurodegenerative research.
Keywords:
Brain organoidsEpigenetic landscapeMicroglial maturationSingle-cell RNA sequencingiPSC-derived microglia

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