Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering hidden factors of cognitive resilience in Alzheimer's disease using a conditional-Gaussian mixture variational autoencoder.

NPJ dementia·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The genetic architecture of fibromyalgia across 2.5 million individuals.

medRxiv : the preprint server for health sciences·2025
Same author

Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups.

bioRxiv : the preprint server for biology·2025
Same author

CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density.

Neuron·2025
Same journal

Towards ecological psychiatry: The herbicide glyphosate disrupts behavior through microbiota-gut-brain axis.

Molecular psychiatry·2026
Same journal

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry·2026
Same journal

Serotonergic SLC10A4 regulates extracellular serotonin levels and antidepressant responsiveness.

Molecular psychiatry·2026
Same journal

TranDep: a transcriptomics atlas of depression.

Molecular psychiatry·2026
Same journal

Effects of cannabidiol on anxiety- and depressive-like behaviors and cognition: a systematic review and meta-analysis of preclinical studies.

Molecular psychiatry·2026
Same journal

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Molecular psychiatry·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
05:45

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies

Published on: March 29, 2024

3.4K

Single-cell transcriptomics of human brain disorders.

Keon Arbabi1,2,3, Giuseppe Carito1, Tain Luquez4

  • 1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

Molecular Psychiatry
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Single-cell genomics reveals cellular changes in brain diseases, mapping how neurological and psychiatric disorders affect specific cell types in the human brain. This research provides crucial insights into disease mechanisms at the cellular level.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K
Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq
06:22

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Published on: August 25, 2020

12.3K

Related Experiment Videos

Last Updated: Apr 22, 2026

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
05:45

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies

Published on: March 29, 2024

3.4K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K
Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq
06:22

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Published on: August 25, 2020

12.3K

Area of Science:

  • Neuroscience
  • Genomics
  • Cell Biology

Background:

  • Brain diseases stem from cellular dysfunction.
  • Single-cell genomics offers new insights into these cellular pathologies.
  • Understanding cellular changes is key to diagnosing and treating brain disorders.

Purpose of the Study:

  • To synthesize key biological insights from recent single-cell studies of post-mortem human brain tissue.
  • To explore cellular pathologies underlying neurological and psychiatric conditions.
  • To map how these disorders manifest across the human brain's cellular landscape.

Main Methods:

  • Review of recent single-cell genomics studies on post-mortem human brain tissue.
  • Organization of findings by central nervous system cell type.
  • Analysis of cellular population changes, disease-associated states, and gene expression dysregulation.

Main Results:

  • Identification of depleted vulnerable cell populations in various brain diseases.
  • Characterization of disease-associated cellular states and their emergence.
  • Detailed analysis of gene expression program dysregulation and its link to genetic risk factors.

Conclusions:

  • Single-cell genomics is revolutionizing brain disease research.
  • Comprehensive cellular maps are emerging for neurological and psychiatric disorders.
  • These findings provide a turning point for understanding brain disease at the cellular level.