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Related Experiment Video

Updated: Apr 22, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Bio-inspired White Tablet Coating Film Without Titanium Dioxide.

Yutong Tian¹, Shihao Song¹, Yaojie Shi¹

¹School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Pharmaceutical Research

|April 20, 2026

Summary

Developing novel titanium dioxide-free white tablet coatings, this study uses bioinspired porous films made from polyvinyl alcohol and polyethylene glycol. These coatings achieve high whiteness, offering a safer alternative for the pharmaceutical and food industries.

Keywords:

calcium carbonate phase separation polyvinyl alcohol tablet coating whiteness titanium dioxide-free coating

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TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method

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Published on: April 26, 2017

Area of Science:

Materials Science
Biomimetics
Polymer Science

Background:

Titanium dioxide (TiO2) is a common white additive in food and pharmaceuticals but faces safety concerns.
Calcium carbonate is a less effective TiO2 alternative, offering inferior whiteness in tablet coatings.
There is a growing demand for TiO2-free and pigment-free white tablet coatings in the health industry.

Purpose of the Study:

To develop a novel strategy for TiO2-free white tablet coatings.
To investigate the potential of bioinspired porous films for enhanced whiteness.
To explore polymer-polymer phase separation for creating white film coatings.

Main Methods:

Fabrication of porous films using phase separation between polyvinyl alcohol (PVA) and polyethylene glycol (PEG).
Utilizing the refractive index difference between polymer and air to generate light scattering.
Investigating the light-shielding effect of calcium carbonate with different morphologies.

Main Results:

Porous PVA/PEG films achieved high CIELab whiteness (above 80, up to 87) when using calcium carbonate as an opacifier.
The porous films significantly outperformed dense films made with lipid plasticizers in terms of whiteness.
Quasi-rhombohedral calcium carbonate enhanced whiteness by 8.2% compared to spindle aggregates within the same porous structure.

Conclusions:

Porous structures are key to improving whiteness in tablet coatings.
Bioinspired porous films created via polymer-polymer phase separation offer a new approach for TiO2-free white tablet coatings.
This strategy can guide the selection of other phase-separating polymers to enhance film whiteness and overall properties.