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Updated: Apr 22, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

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Metabolic syndrome predicts cardiovascular and all-cause adverse outcomes in patients with chronic inflammatory

Zhuoran Li1, Tingting Zou2, Yadong Li3

  • 1Shanxi Medical University, Taiyuan, 030001, China.

Clinical Rheumatology
|April 20, 2026
PubMed

Insights

Metabolic syndrome (MetS) significantly increases cardiovascular and all-cause risks in patients with chronic inflammatory arthritis (CIA). Each additional MetS component further elevates cardiovascular risk, highlighting the importance of managing MetS in this population.

Area of Science:

  • Rheumatology
  • Cardiology
  • Metabolic Diseases

Background:

  • Chronic inflammatory arthritis (CIA) is linked to higher cardiovascular risk.
  • Metabolic syndrome (MetS) is common in CIA patients and may worsen outcomes.

Purpose of the Study:

  • To determine if MetS independently predicts adverse cardiovascular and all-cause events in CIA patients.
  • To assess the relationship between the number of MetS components and patient prognosis.

Main Methods:

  • Prospective observational study of 811 CIA patients.
  • Propensity score matching (PSM) used to balance groups.
  • Cox regression and Kaplan-Meier analyses for outcome evaluation.

Main Results:

  • MetS was present in 35% of patients.
  • Patients with MetS had significantly higher rates of cardiovascular (18.4% vs 7.7%) and all-cause events (37.8% vs 19.9%).
  • MetS independently predicted cardiovascular (aHR=4.12) and all-cause outcomes (aHR=2.81). Each additional MetS component increased cardiovascular risk by 1.68-fold.

Conclusions:

  • MetS is an independent risk factor for adverse cardiovascular and all-cause outcomes in CIA patients.
  • A dose-response relationship exists: more MetS components lead to higher cardiovascular risk.
Abstract

Keywords:
Cardiovascular riskChronic inflammatory arthritisCox regressionMetabolic syndromePropensity score matching

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