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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 21, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
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From Rescue to Risk: Challenges and Controversies in Pushing the Boundaries of Organ Utilization by Machine

Damiano Patrono1, Rebecca Panconesi1, Nicola De Stefano1

  • 1General Surgery 2U-Liver Transplant Center, Department of Surgery and Transplantation, AOU Città Della Salute e Della Scienza di Torino, Turin, Italy.

Artificial Organs
|April 20, 2026
PubMed
Summary

Extended criteria donor (ECD) livers and machine perfusion (MP) expand organ availability for liver transplantation (LT). Viability assessment during MP is crucial but inconsistent, necessitating standardized protocols for improved outcomes.

Keywords:
flavin mononucleotidelactateliver transplantationmachine perfusionorgan utilizationviability assessment

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Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Surgical Innovation

Background:

  • Donor liver shortage necessitates utilizing Extended Criteria Donors (ECD).
  • Ex-situ Machine Perfusion (MP) enhances organ preservation and logistics for liver transplantation (LT).
  • MP enables real-time viability assessment to predict post-transplant liver function.

Purpose of the Study:

  • To review current MP viability assessment protocols in LT.
  • To explore emerging viability biomarkers for improved assessment.
  • To discuss the need for an operational definition of viability assessment.

Main Methods:

  • Literature review of existing viability assessment protocols.
  • Summary of studies on novel viability biomarkers during MP.
  • Discussion of challenges and future directions in viability assessment.

Main Results:

  • Current viability assessment protocols are inconsistent.
  • Emerging biomarkers show promise but require further validation.
  • Standardization of viability assessment is critical for clinical application.

Conclusions:

  • Machine perfusion viability assessment holds potential to expand the donor pool.
  • Further research and a defined operational definition are needed for consistent application.
  • Improved viability assessment can enhance liver transplantation outcomes.