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Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain

Qiaoyun Wu1,2, Yuewei Chen1,2, Xintong Yao2

  • 1Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

The Journal of Headache and Pain
|April 21, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
FGF4GlycolysisImmune inflammationNeuropathic painSynaptic plasticity

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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