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A single-cell multi-omics atlas defines the cellular and molecular landscape of gastric intestinal metaplasia

Yuman Ye1,2, Xiaomin Gong1, Sujuan Liu1

  • 1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

Journal of Translational Medicine
|April 21, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Gastric intestinal metaplasiaNEDD8ProteomeScRNA-seq

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DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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