Related Experiment Video
Updated: May 7, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
The Impact of Periodontal Health Interventions on the Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis
Jorge Moldes1,2, Joao Botelho3, Manuel Rodríguez-Yáñez4
1Family and Community Medicine Department, Bueu Health Centre, Pontevedra University Clinical Hospital, Pontevedra, Spain.
Aim:
To systematically review the evidence on the relationship between periodontal health interventions and the risk of first-ever ischemic stroke.
Materials And Methods:
Search strategy included electronic and hand searching to January 2025. MEDLINE (OVID), EMBASE (OVID), SCOPUS, LILACS, Web of Science (WOS) and Cochrane Central Register of Controlled Trials (CENTRAL) were searched. Eligible studies included clinical trials and observational designs reporting on any periodontal health intervention and ischemic stroke. Screening and data extraction were performed independently and in duplicate. Meta-analyses were conducted when appropriate.
Results:
Seven studies involving 1,886,947 participants met the inclusion criteria from an initial set of 634 records. In a random-effects meta-analysis, periodontal interventions were associated with a lower risk of ischemic stroke (HR: 0.88 [0.81-0.95]). Tooth scaling, in particular, was associated with a reduced risk (HR: 0.84 [0.76-0.92]).
Conclusion:
Periodontal health interventions-especially tooth scaling-appear to be associated with a lower risk of ischemic stroke. These findings suggest a potential role for periodontal care in stroke prevention.
Trial Registration:
PROSPERO number: CRD42023450471.
More Related Videos
06:06Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
06:36Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
Published on: March 14, 2025
Related Concept Videos
Coronary Artery Disease IV: Preventive Measures
Acute Coronary Syndrome IV: Interprofessional Care
Atherosclerosis III: Management
Peripheral Artery Disease III: Interprofessional Care
The Oral Microbiota
Ischemic Stroke l: Introduction