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Identifying Nurses at Risk of Nursing Interruptions During Medication Administration Using Machine Learning: A

Xiaoqian Dong1,2, Siqing Ding1,3, Sha Wang1,4

  • 1Nursing Department, Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China, csu.edu.cn.

Journal of Nursing Management
|April 21, 2026
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Summary
This summary is machine-generated.

This study developed machine learning models to predict nursing interruptions during medication administration (NIMA). The logistic regression model showed the best performance, offering a tool for targeted nursing management.

Keywords:
machine learningmedication safetynursesnursing interruptionrisk prediction model

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Area of Science:

  • Nursing Science
  • Health Informatics
  • Machine Learning in Healthcare

Background:

  • Nursing interruptions during medication administration (NIMA) are a significant cause of medication errors.
  • Validated tools for assessing NIMA risk are currently lacking.
  • This study addresses the need for predictive models to identify nurses at high risk for NIMA.

Purpose of the Study:

  • To develop and internally validate three machine learning models: logistic regression (LR), decision tree (DT), and Naive Bayes (NB).
  • To identify individual nurses' risk of experiencing NIMA.
  • To provide a foundation for targeted nursing interventions.

Main Methods:

  • Recruited 4758 Chinese nurses from 12 tertiary hospitals.
  • Developed and validated LR, DT, and NB models using training (80%) and internal validation (20%) sets.
  • Evaluated model performance using AUC, accuracy, recall, specificity, precision, F1-score, and G-mean, with DeLong and Hosmer-Lemeshow tests for comparison and calibration.

Main Results:

  • Over half (52.1%) of nurses experienced at least one NIMA event.
  • Identified 18 predictive factors for NIMA, including department type, marital status, and self-efficacy.
  • The LR model demonstrated the highest performance with an AUC of 0.748 and good calibration.

Conclusions:

  • Successfully developed and internally validated three NIMA risk prediction models.
  • The LR-based nomogram and web calculators show promise for risk stratification and management.
  • Further external validation and feasibility assessments are recommended before clinical implementation.