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Updated: Apr 22, 2026

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

Published on: April 29, 2020

Real-World Utilization Patterns of Toxoplasmosis Diagnostic Testing in Korea: A Large-Scale Laboratory-Based Study.

Rihwa Choi^1,2, Sang Gon Lee¹

¹Laboratory Medicine Center, GC Labs, Yongin, Gyeonggi, Republic of Korea.

Journal of Clinical Laboratory Analysis

|April 21, 2026

Summary

This study reveals varied diagnostic test use for toxoplasmosis in Korea. Serologic tests dominate initial evaluations, with PCR used sparingly, highlighting a need for clearer clinical guidelines.

Keywords:

immunoglobulin G immunoglobulin M polymerase chain reaction test utilization toxoplasma

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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

Area of Science:

Medical Diagnostics
Infectious Disease Epidemiology
Clinical Laboratory Science

Background:

Toxoplasmosis diagnosis relies mainly on serologic assays, with PCR used selectively.
Real-world data on toxoplasmosis diagnostic test utilization is scarce, especially in low-prevalence regions.
Understanding current diagnostic practices is crucial for optimizing patient care and resource allocation.

Purpose of the Study:

To analyze real-world utilization patterns of Toxoplasma gondii diagnostic tests in Korea.
To investigate test combinations, sequential testing, and factors influencing test positivity.
To identify variations in diagnostic approaches across different healthcare institutions.

Main Methods:

Retrospective analysis of laboratory data for PCR, IgG, and IgM assays from January 2020 to December 2024.
Evaluation of 28,668 subjects undergoing toxoplasmosis testing.
Descriptive statistics and multivariable logistic regression for analyzing utilization and positivity factors.

Main Results:

Serologic tests were the primary initial diagnostic method; PCR was infrequently used as an adjunct.
IgM positivity correlated with subsequent testing, while IgG positivity increased with age.
PCR positivity indicating acute infection was rare, found mainly in cerebrospinal and vitreous fluids.
Significant institutional variations in testing patterns were observed.

Conclusions:

This study offers a comprehensive overview of toxoplasmosis diagnostic test usage in Korea.
Observed variations in test utilization, particularly IgM use and sequential testing, warrant further investigation.
Clinical data integration is essential to fully understand the implications of these diagnostic patterns.