Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

14.3K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.3K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Effects of Poly(ε-Caprolactone)-Nanohydroxyapatite Composition on 3D-Printed Scaffold Structural Properties.

Journal of biomedical materials research. Part A·2026
Same author

Comparison of innovative medical devices between China and the United States.

Regenerative biomaterials·2026
Same author

Bone matrix-inspired whitlockite porous ceramic with effects of autophagy activation contributes to bone regeneration.

Bioactive materials·2026
Same author

3D Printing Colloidal Gels: Navigating the Printability Barrier.

Tissue engineering. Part C, Methods·2025
Same author

Extracellular-Matrix-Based Materials from Decellularized Tissue: Opportunities, Challenges, and Future Directions in Regenerative Medicine.

Advanced healthcare materials·2025
Same author

<i>In Vitro</i> and <i>In Vivo</i> Evaluation of a Bovine Collagen Matrix for Acute Rotator Cuff Tear Repair.

Tissue engineering. Part A·2025
Same journal

Polymer-Zn(II) sunscreens for protection against harmful blue ray.

Bioactive materials·2026
Same journal

M1 macrophage-derived exosomal miR-155-5p exacerbates aortic dissection via SMAD5-Mediated regulation of vascular smooth muscle cell phenotype.

Bioactive materials·2026
Same journal

Immunity-and-matrix-regulatory cells promote hyaline-like cartilage repair in osteoarthritis.

Bioactive materials·2026
Same journal

Injectable chondroitin sulfate-glycosylated decellularized extracellular matrix microgels activate Wnt/β-Catenin signaling to promote functional muscle regeneration in VML.

Bioactive materials·2026
Same journal

4D piezoceramic-integrated scaffolds with bioelectric cues for skeletal muscle regeneration.

Bioactive materials·2026
Same journal

Metal-phenolic nanocapsules enable a self-amplifying cuproptosis-STING cascade for synergistic cancer immunotherapy.

Bioactive materials·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

65

Topographical design principles for osteochondral tissue engineering.

Lucia Aboal-Castro1, Vasiliki K Kolliopoulos2, Carmen Alvarez-Lorenzo1

  • 1I+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Institute of Materials (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.

Bioactive Materials
|April 21, 2026
PubMed
Summary
This summary is machine-generated.

Surface topography significantly influences cartilage and bone regeneration. Nanoscale features promote cartilage growth, while microscale features enhance bone formation, guiding future biomaterial design for osteochondral repair.

Keywords:
Bioactive scaffoldBoneCartilageOsteochondral repairTopography

More Related Videos

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

17.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.8K

Related Experiment Videos

Last Updated: Apr 22, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

65
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

17.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.8K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • The osteochondral unit's complex structure presents challenges for tissue engineering.
  • Surface topography is a critical, yet underutilized, factor in scaffold design for osteochondral regeneration.

Purpose of the Study:

  • To systematically review the impact of surface topography, specifically feature size and anisotropy, on cartilage and bone regeneration.
  • To provide design principles for biomaterials aimed at functional osteochondral repair.

Main Methods:

  • Systematic review of in vitro and in vivo studies.
  • Analysis of topographical features (nanoscale vs. microscale, isotropic vs. anisotropic).

Main Results:

  • Nanoscale, isotropic topographies favor chondrogenesis and cartilage matrix formation.
  • Microscale topographies generally promote osteogenesis and bone mineralization.
  • Anisotropic topographies enhance tissue-specific cell alignment and matrix organization.

Conclusions:

  • Surface topography is a key parameter for coordinating osteochondral regeneration.
  • Combining multi-scale and graded topographies can mimic natural architecture for improved repair.
  • This review offers practical design principles for next-generation osteochondral biomaterials.